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Abstract #3442

Neurometabolic Analysis in Amyotrophic Lateral Sclerosis: A 1H-[13C]-NMR investigation

Dipak Roy1 and Anant Bahadur Patel1
1NMR Microimaging and Spectroscopy Facility, Centre for Cellular and Molecular Biology, Hyderabad, India

In this study we have evaluated the neurometabolic activity of a transgenic (SOD1G37R) mouse model of ALS by 1H-[13C]-NMR spectroscopy together with an infusion of 13C labeled substrates (glucose/acetate). Reduced motor performance and abnormal gait were observed in 18-month old male SOD1G37R mice. The glutamatergic and GABAergic neurometabolic rates were decreased, while astroglial metabolic flux was increased in the spinal cord of the SOD1G37R mice. In contrast, neuronal and astroglial metabolic activities were increased in the cerebral cortex of these mice.

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