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Abstract #3443

3D-MP2RAGE T1 mapping to characterize regional cervical spinal cord impairments in ALS and MS patients.

Samira Mchinda1,2, Sarah Demortière3, Henitsoa Rasoanandrianina4, Claire Costes1,2, Jean Pelletier2,5, Shahram Attarian6, Aude-Marie Grapperon6, Bertrand Audoin2,5, Annie Vershueren6, and Virginie Callot1,2
1Aix-Marseille Univ, CNRS, CRMBM, Marseille, France, 2APHM, Hôpital Universitaire Timone, CEMEREM, Marseille, France, 3APHM, Hôpital Universitaire Timone, Neurology Department, Marseille, France, 4Departement of Research and Innovation, Olea Medical, La Ciotat, France, 5. APHM, Hôpital Universitaire Timone, Neurology Department, Marseille, France, 6APHM, Hôpital Universitaire Timone, Reference Center for Neuromuscular Disorders and ALS, Marseille, France

The MP2RAGE sequence has never been applied for T1 quantification in the context of neurodegenerative spinal cord pathologies. In this study, the technique demonstrated good discrimination between WM and GM in healthy controls, better detection of cervical lesions in Multiple Sclerosis patients, and increased T1 values in corticospinal tracts of both Amyotrophic Lateral Sclerosis patients and MS patients , and lateral sensory tracts of MS patients. Very robust and compatible with clinical scan time, the MP2RAGE may be a technique of choice for longitudinal studies.

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