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Abstract #3445

Characterizing 1-Year Development of Cervical Cord Atrophy Across Different MS Phenotypes: A Voxel-Wise, Multicenter Analysis

Paola Valsasina1, Maria A. Rocca1,2,3, Claudio Gobbi4,5, Chiara Zecca4,5, Alex Rovira6, Xavier Montalban7, Hugh Kearney8, Olga Ciccarelli8, Lucy Matthews9, Jacqueline Palace9, Antonio Gallo10, Alvino Bisecco10, Achim Gass11, Philipp Eisele11, and Massimo Filippi1,2,3,12,13
1Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy, 2Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy, 3Vita-Salute San Raffaele University, Milan, Italy, 4Multiple Sclerosis Center, Department of Neurology, Neurocenter of Southern Switzerland, Civic Hospital, Lugano, Switzerland, 5Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland, 6Section of Neuroradiology, Department of Radiology, Hospital Universitari Vall d’Hebron, Barcelona, Spain, 7Department of Neurology/Neuroimmunology, Multiple Sclerosis Center of Catalonia, Hospital Universitari Vall d’Hebron, Barcelona, Spain, 8NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Institute of Neurology, London, United Kingdom, 9Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, 10Department of Advanced Medical and Surgical Sciences, and 3T MRI Center, University of Campania “Luigi Vanvitelli”, Naples, Italy, 11Department of Neurology, Universitätsmedizin Mannheim, University of Heidelberg, Mannheim, Germany, 12Neurorehabilitation Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy, 13Neurophysiology Service, IRCCS San Raffaele Scientific Institute, Milan, Italy

Here, we used a longitudinal, voxel-wise analysis to characterize baseline cervical cord tissue loss and its progression over 1-year follow-up in a cohort of patients with multiple sclerosis (MS) acquired at 7 European sites. Results indicated that baseline cord atrophy was severe in MS patients vs controls, with a prevalent involvement of posterior/lateral regions of the upper cord, a differential effect across phenotypes and a strong correlation with disability. Cord atrophy significantly increased over time in all MS patients, was more widespread in relapsing-remitting MS than in other phenotypes and contributed to explain clinical disability at 1-year follow-up.

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