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Abstract #3446

Free Water Eliminated White Matter Tract Integrity of Spinal Cord in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder

Masaaki Hori1,2, Kouhei Kamiya1,2, Akifumi Hagiwara2,3, Kazumasa Yokoyama4, Issei Fukunaga5, Katsuhiro Sano2, Koji Kamagata2, Katsutoshi Murata6, Shohei Fujita2, Christina Andica2, Akihiko Wada2, Julien Cohen-Adad7, and Shigeki Aoki2
1Radiology, Toho University Omori Medical Center, Tokyo, Japan, 2Radiology, Juntendo University School of Medicine, Tokyo, Japan, 3Radiology, David Geffen School of Medicine, Los Angeles, CA, United States, 4Neurology, Juntendo University School of Medicine, Tokyo, Japan, 5Juntendo University School of Medicine, Tokyo, Japan, 6Siemens Japan K.K, Tokyo, Japan, 7NeuroPoly Lab, Polytechnique Montreal, Montréal, QC, Canada

We investigated free water eliminated kurtosis-based white matter tract integrity to distinguish microstructural changes in the spinal cords of patients with MS and Neuromyelitis Optica. FA was significant higher in spinal cord white matter in MS (P=0.0025). There was no significant difference in other diffusion model-based metrics. The values of FA seem to be non-specific but robust. Therefore, clinical feasible and more optimized diffusion microstructural models and data acquisitions for spinal cord may be needed to provide an additional information and to be biomarker in patients with MS and NMOSD in vivo.

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