Abstract #3446

Free Water Eliminated White Matter Tract Integrity of Spinal Cord in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder

Masaaki Hori^1,2, Kouhei Kamiya^1,2, Akifumi Hagiwara^2,3, Kazumasa Yokoyama⁴, Issei Fukunaga⁵, Katsuhiro Sano², Koji Kamagata², Katsutoshi Murata⁶, Shohei Fujita², Christina Andica², Akihiko Wada², Julien Cohen-Adad⁷, and Shigeki Aoki²

¹Radiology, Toho University Omori Medical Center, Tokyo, Japan, ²Radiology, Juntendo University School of Medicine, Tokyo, Japan, ³Radiology, David Geffen School of Medicine, Los Angeles, CA, United States, ⁴Neurology, Juntendo University School of Medicine, Tokyo, Japan, ⁵Juntendo University School of Medicine, Tokyo, Japan, ⁶Siemens Japan K.K, Tokyo, Japan, ⁷NeuroPoly Lab, Polytechnique Montreal, Montréal, QC, Canada

We investigated free water eliminated kurtosis-based white matter tract integrity to distinguish microstructural changes in the spinal cords of patients with MS and Neuromyelitis Optica. FA was significant higher in spinal cord white matter in MS (P=0.0025). There was no significant difference in other diffusion model-based metrics. The values of FA seem to be non-specific but robust. Therefore, clinical feasible and more optimized diffusion microstructural models and data acquisitions for spinal cord may be needed to provide an additional information and to be biomarker in patients with MS and NMOSD in vivo.

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