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Abstract #3448

Feasibility of cervical spinal cord cross-sectional measurements from 3D T1w sagittal head MRI at 7T

Vanessa Wiggermann1, Henrik Lundell1, Mads Alexander Just Madsen1, Christopher Fugl Madelung1, and Hartwig Roman Siebner1,2,3
1Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark, 2Dept. of Neurology, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark, 3Institute for Clinical Medicine, Faculty of Medical and Health Sciences, University of Copenhagen, Copenhagen, Denmark

Spinal cord atrophy is a highly relevant measure of disease progression in multiple sclerosis. Here, we assessed whether cord area measurements from head MRI scans at 7T are feasible with semi- and fully-automated tools. Although different tools can yield systematically different absolute cord areas, measurements were highly consistent within studies as well as across field strengths, if images with similar voxel sizes were used. At higher spatial resolution, the volume of partial signal voxels is reduced and smaller cord areas and diameters were measured than typically reported in literature.

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