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Abstract #3449

Quantitative Magnetic Resonance Imaging Assessment of Cervical Spinal Cord Injury in Rats

Seung Yi Lee1, Shekar Kurpad2, and Matthew Budde2
1Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States, 2Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, United States

This work aims to investigate the relationship neurological outcomes from a cervical contusion spinal cord injury model in rats with early MRI markers including edema, hemorrhage, and diffusion weighted imaging. A rat-specific MRI template was constructed from a histological atlas to permit inter-subject registration. Compared to diffusion tensor imaging (DTI) metrics, filtered-DWI diminished the confounding effects of vasogenic edema and improved depiction of the acute damage. Collectively, the registration pipeline facilitated analysis, and the results support the role of MRI in preclinical assessment of cervical SCI.

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