The application of lower body negative pressure in the supine position significantly reduces bulk cerebral arterial flow and cross-sectional area of the internal jugular vein compared to the supine position alone. This is similar to the physiologic response expected with upright compared to supine positioning. Our results suggest that lower body negative pressure applied during spaceflight may help reduce headward fluid shift and venous congestion and mitigate the development of optic disc edema associated with long-duration spaceflight.
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