Meeting Banner
Abstract #3465

Spaceflight Associated Neuro-Ocular Syndrome: Quantitative MRI Evaluation of Lower Body Negative Pressure as a Potential Countermeasure

Larry A. Kramer1, Khader M. Hasan1, Brandon R. Macias2, Karina J. Marshall-Goebel3, Steven S. Laurie3, Refaat E. Gabr1, Leela Chaudhary1, and Alan R. Hargens4
1Diagnostic Imaging, UTHSC-Houston, Houston, TX, United States, 2NASA, Houston, TX, United States, 3KBR, Houston, TX, United States, 4Orthopedic Surgery, UCSD, La Jolla, CA, United States

The application of lower body negative pressure in the supine position significantly reduces bulk cerebral arterial flow and cross-sectional area of the internal jugular vein compared to the supine position alone. This is similar to the physiologic response expected with upright compared to supine positioning. Our results suggest that lower body negative pressure applied during spaceflight may help reduce headward fluid shift and venous congestion and mitigate the development of optic disc edema associated with long-duration spaceflight.

This abstract and the presentation materials are available to members only; a login is required.

Join Here