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Abstract #3558

Optimizing Acquisition and Analysis for Diffusion Weighted Hyperpolarized 129Xe MRI of Pediatric and Adult Lungs

Abdullah S. Bdaiwi1,2, Peter J. Nedbalski1, Md M. Hossain3, Matthew M. Willmering1, Laura L. Walkup1,2,4, Hui Wang5, Robert P. Thomen1, Kai Ruppert1, Jason C. Woods1,4,6, and Zackary I. Cleveland1,2,4,6
1Center for Pulmonary Imaging Research, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 2Biomedical Engineering Department, University of Cincinnati, Cincinnati, OH, United States, 3Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 4Division of Pulmonary Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States, 5Philips, Cincinnati, OH, United States, 6Department of Pediatrics, University of Cincinnati, Cincinnati, OH, United States

Hyperpolarized (HP) 129Xe MRI can non-invasively quantify lung microstructure through measuring the gas-phase apparent diffusion coefficient (ADC), providing insights into disease pathophysiology—e.g., emphysema severity. To maximize the utility of this method, we developed an analytical model, based on HP-specific Bloch equations and error propagation, to optimize ADC measurements in terms of acquisition parameters (b-value, flip angle, phase encodes, etc.) and the ADC itself and validated this model via Monte Carlo and phantom studies. Finally, a lower bound on the expected 129Xe ADC was obtained by measuring ADC as a function of age in human subjects as young as six years.

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