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Abstract #3559

Assessment of dynamic airflow heterogeneity after bronchodilator in asthma using hyperpolarized helium-3 MRI

Mu He1, Lindsay A. Somerville1, Nicolas J. Tustison1, James Patrie1, Jaime F. Mata1, Joanne M. Cassani2, Roselove Nunoo-Asare1, Alan Ropp1, Wilson G. Miller1, Yun Michael Shim1, Talissa A. Altes2, John P. Mulger1, and Eduard E. de Lange1
1University of Virginia, Charlottesville, VA, United States, 2University of Missouri, Columbia, MO, United States

With hyperpolarized helium-3 (3He) MRI regional differences in airflow heterogeneity can be assessed. In this study, we used weighted entropy to evaluate dynamic ventilation heterogeneity in asthmatics. Serial 3He/1H scans were co-registered and normalized for comparison. Weighted entropy was calculated based on entropy and Ventilation defect percentage (VDP) values derived from normalized 3He scans. Lobar analysis was performed to identify lobar weighted entropy. We found that asthmatics have more heterogeneous ventilation distribution in the lower lobes at baseline. Variable airflow heterogeneity changes were observed globally in asthmatics, with the most significant bronchodilator response in the left lung.

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