Meeting Banner
Abstract #3569

Detection of pulmonary abnormalities in a rabbit thoracic insufficiency syndrome model using hyperpolarized xenon-129 MRI

Kai Ruppert1, Faraz Amzajerdian1, Yi Xin1, Hooman Hamedani1, Luis Loza1, Tahmina S Achekzai1, Ryan J Baron1, Ian F Duncan1, Harrilla Profka1, Yiwen Qian1, Stephen Kadlecek1, Alessandra Fusco2, Benjamin Sinder3, Patrick J Cahill3, Brian Snyder3,4, Thomas P Schaer2, and Rahim R Rizi1
1University of Pennsylvania, Philadelphia, PA, United States, 2School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA, United States, 3Children's Hospital of Philadelphia, Philadelphia, PA, United States, 4Boston Children's Hospital, Boston, MA, United States

Thoracic insufficiency syndrome (TIS) progresses to the development of restrictive lung disease and is commonly treated through surgical intervention. In this work, we used a rib-tether rabbit model to investigate the sensitivity of dynamic 1D simultaneous dissolved- and gas-phase hyperpolarized xenon-129 MRI imaging to pulmonary abnormalities secondary to TIS. We found asymmetric lung ventilation patterns and increases in alveolar septal wall thickness in both lungs of a rib-tethered rabbit compared to an age-matched control animal. These findings could help identify the optimal timepoint at which to conduct chest expansion surgery so as to maximize the resulting improvements in lung maturation.

This abstract and the presentation materials are available to members only; a login is required.

Join Here