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Abstract #3568

Background field inhomogeneity effects on hyperpolarized 129Xe diffusion-weighted MRI at 1.5T and 3T

Ho-Fung Chan1, Guilhem J Collier1, Madhwesha Rao1, and Jim M Wild1
1Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom

Background field inhomogeneities due to air-tissue interface magnetic susceptibility differences in the lungs increases derived ADC measurements from 3He PGSE diffusion-weighted (DW) lung MRI at higher field strengths. To determine if the same effects are observed with 129Xe DW-MRI, 129Xe ADC and mean diffusive length scale (LmD) from healthy volunteers imaged at 1.5T and 3T were compared. A small bias towards increased 129Xe ADC (6.3%) and LmD (2.2%) values at 3T was obtained, which is smaller than the reported bias of 3He ADC (15.5%) and 3He mean chord length (10.5%), and similar to the reported 129Xe DW-MRI inter-scan repeatability differences.

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