Abstract #3574

The effects of an initial depolarization pulse on the dissolved phase hyperpolarized 129Xe images

Yurii Shepelytskyi^1,2, Vira Grynko^1,2, Tao Li³, Ayman Hassan^4,5, Karl Granberg⁴, and Mitchell S Albert^2,3,5

¹Chemistry and Materials Science Program, Lakehead University, Thunder Bay, ON, Canada, ²Thunder Bay Regional Health Research Institute, Thunder Bay, ON, Canada, ³Chemistry, Lakehead University, Thunder Bay, ON, Canada, ⁴Thunder Bay Regional Health Sciences Centre, Thunder Bay, ON, Canada, ⁵Northern Ontario School of Medicine, Thunder Bay, ON, Canada

Hyperpolarized (HP) xenon-129 (¹²⁹Xe) freely dissolves in pulmonary blood and travels to highly perfused organs. Dissolved phase HP ¹²⁹Xe imaging is commonly used for evaluating gas-blood exchange in lungs, imaging cerebral perfusion, detecting hemodynamic response, and kidney perfusion. However, the signal-to-noise ratio (SNR) of HP ¹²⁹Xe dissolved phase images varies between breath-holds, especially for brain imaging. In this work, we demonstrated a significant reduction in the variability of MRI image SNR by implementing an additional depolarization pulse prior to image acquisition.

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