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Abstract #3574

The effects of an initial depolarization pulse on the dissolved phase hyperpolarized 129Xe images

Yurii Shepelytskyi1,2, Vira Grynko1,2, Tao Li3, Ayman Hassan4,5, Karl Granberg4, and Mitchell S Albert2,3,5
1Chemistry and Materials Science Program, Lakehead University, Thunder Bay, ON, Canada, 2Thunder Bay Regional Health Research Institute, Thunder Bay, ON, Canada, 3Chemistry, Lakehead University, Thunder Bay, ON, Canada, 4Thunder Bay Regional Health Sciences Centre, Thunder Bay, ON, Canada, 5Northern Ontario School of Medicine, Thunder Bay, ON, Canada

Hyperpolarized (HP) xenon-129 (129Xe) freely dissolves in pulmonary blood and travels to highly perfused organs. Dissolved phase HP 129Xe imaging is commonly used for evaluating gas-blood exchange in lungs, imaging cerebral perfusion, detecting hemodynamic response, and kidney perfusion. However, the signal-to-noise ratio (SNR) of HP 129Xe dissolved phase images varies between breath-holds, especially for brain imaging. In this work, we demonstrated a significant reduction in the variability of MRI image SNR by implementing an additional depolarization pulse prior to image acquisition.

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