Abstract #3575

2D and 3D Spiral for Diffusion Weighted MRI with Hyperpolarized 129Xe

Abdullah S. Bdaiwi^1,2, Matthew M. Willmering¹, Hui Wang³, and Zackary I. Cleveland^1,2,4,5

¹Center for Pulmonary Imaging Research, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, ²Biomedical Engineering Department, University of Cincinnati, Cincinnati, OH, United States, ³Philips, Cincinnati, OH, United States, ⁴Department of Pediatrics, University of Cincinnati, Cincinnati, OH, United States, ⁵Division of Pulmonary Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States

Diffusion-weighted hyperpolarized ¹²⁹Xe MRI is a validated measure of lung microstructure and can assess changes in alveolar dimensions. These images are commonly acquired via 2D gradient recalled echo (GRE), but ¹²⁹Xe GRE images suffer from coarse resolution in the slice dimension and breath-hold durations (≤16 s) that may be difficult for pediatric and severely ill subjects. To overcome these limitations, we implemented 2D- and 3D-spiral (FLORET, Fermat looped, orthogonally encoded trajectories) sequences for ¹²⁹Xe diffusion imaging. These sequences enable either rapid acquisition or high-resolution, isotropic lung coverage and display image quality and ADC accuracy comparable to that of conventional 2D-GRE.

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