Abstract #3576

Evaluating the Fractal Nature of 129Xe MRI Ventilation Heterogeneity

Rachel L Eddy^1,2, Alexander M Matheson^3,4, Marrissa J McIntosh^3,4, and Grace Parraga^3,4

¹St. Paul's Hospital, UBC Centre for Heart Lung Innovation, Vancouver, BC, Canada, ²Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, BC, Canada, ³Robarts Research Institute, London, ON, Canada, ⁴Department of Medical Biophysics, Western University, London, ON, Canada

Pulmonary ventilation has been shown to follow a fractal distribution using fluorescence imaging. ¹²⁹Xe MRI provides high spatial-temporal resolution images of pulmonary ventilation so here, we aimed to determine the fractal properties of ¹²⁹Xe MRI ventilation heterogeneity using the box-counting method. In 25 patients with asthma, MRI ventilation heterogeneity followed a power law and mean fractal dimension for MRI signal ranged from 1.39-1.82. Fractal analysis can provide a new tool to measure regional MRI ventilation heterogeneity and investigate pulmonary structure-function relationships in patients with lung disease.

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