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Abstract #3576

Evaluating the Fractal Nature of 129Xe MRI Ventilation Heterogeneity

Rachel L Eddy1,2, Alexander M Matheson3,4, Marrissa J McIntosh3,4, and Grace Parraga3,4
1St. Paul's Hospital, UBC Centre for Heart Lung Innovation, Vancouver, BC, Canada, 2Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, BC, Canada, 3Robarts Research Institute, London, ON, Canada, 4Department of Medical Biophysics, Western University, London, ON, Canada

Pulmonary ventilation has been shown to follow a fractal distribution using fluorescence imaging. 129Xe MRI provides high spatial-temporal resolution images of pulmonary ventilation so here, we aimed to determine the fractal properties of 129Xe MRI ventilation heterogeneity using the box-counting method. In 25 patients with asthma, MRI ventilation heterogeneity followed a power law and mean fractal dimension for MRI signal ranged from 1.39-1.82. Fractal analysis can provide a new tool to measure regional MRI ventilation heterogeneity and investigate pulmonary structure-function relationships in patients with lung disease.

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