Abstract #3579

Hyperpolarized 13C MRI of Fumarate Metabolism for Imaging Necrosis in Hepatitis Mice by Parahydrogen-induced Polarization.

Shingo Matsumoto¹, Neil J. Stewart¹, Hitomi Nakano¹, Takuya Hashimoto², and Hiroshi Hirata¹

¹Information Science and Technologies, Hokkaido University, Sapporo, Japan, ²Department of Chemistry, Chiba University, Chiba, Japan

Hyperpolarized [1-¹³C]fumarate is a promising MRI biomarker for cellular necrosis, which plays an important role in various diseases and cancer treatment response. To demonstrate the feasibility of hyperpolarized MRI of [1-¹³C]fumarate metabolism using parahydrogen-induced polarization (PHIP) – a low-cost alternative to dissolution dynamic nuclear polarization (dDNP), a cost-effective synthetic pathway for high-yield production of a fumarate precursor [1-¹³C]acetylenedicarboxylate was developed. A simple hydrogenative PHIP set-up was used to generate hyperpolarized [1-¹³C]fumarate at sufficient polarization and concentration for in vivo [1-¹³C]fumarate metabolic MRS/MRI in acetaminophen-induced murine model of hepatitis.

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