Meeting Banner
Abstract #3580

Dependency of glycolytic factors in HCC lactate and alanine flux as measured by hyperpolarized 13C MRI

Qianhui Dou1, Aaron K. Grant1, Cody K. Callahan1, Muneeb Ahmed1, and Leo Lee Tsai1
1Radiology, Beth Israel Deaconess Medical Center, Boston, MA, United States

This study investigated the feasibility of hyperpolarized 13C (h13C) MRI as diagnostic tool to monitor hepatocellular carcinoma (HCC) activity. h13C MRI showed significant increase in pyruvate-lactate conversion and decrease in pyruvate-alanine in N1S1 HCC tumors following stimulation from nearby hepatic radiofrequency ablation, while no such changes were seen with the MCA-RH7777 HCC tumors, despite increased tumor burden or proliferation in both cell lines. The h13C measurements matched mRNA expression patterns of glycolysis-related genes, which were relatively lower for MCA-RH7777. h13C pyruvate MRI may provide insight into malignant tumor behavior but is contingent on the activity of key glycolytic regulators.

This abstract and the presentation materials are available to members only; a login is required.

Join Here