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Abstract #3584

Magnetic Resonance Imaging Comparisons of Renal Cell Carcinoma Patient-derived Xenografts

Joao Piraquive1, Hongjuan Zhao2, Rosalie Nolley2, Robert Bok1, James D. Brooks2, Donna M. Peehl1, John Kurhanewicz1, and Renuka Sriram1
1Department of Radiology and Biomedical Imaging, University of California San Francisco, University of California San Francisco, San Francisco, CA, United States, 2Department of Urology, Stanford University, Stanford, CA, United States

We demonstrated substantial morphologic and glycolytic metabolic differences using proton and hyperpolarized 13C magnetic resonance imaging, respectively between and within RCC patient derived xenografts (PDXs). Our findings showed substantial inter-PDX differences in tumor growth rates, as well as the cystic and necrotic components. Furthermore, the xenograft (XEN) established from cell lines derived from the PDX showed significant morphological differences from the parent PDX. Interestingly, upon comparison of two subsequent passages of the same PDX, we found that while the morphological similarities persisted, the glycolytic capacity was significantly increased in the latter passage, implying natural selection of the more aggressive cells.

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