We demonstrated substantial morphologic and glycolytic metabolic differences using proton and hyperpolarized 13C magnetic resonance imaging, respectively between and within RCC patient derived xenografts (PDXs). Our findings showed substantial inter-PDX differences in tumor growth rates, as well as the cystic and necrotic components. Furthermore, the xenograft (XEN) established from cell lines derived from the PDX showed significant morphological differences from the parent PDX. Interestingly, upon comparison of two subsequent passages of the same PDX, we found that while the morphological similarities persisted, the glycolytic capacity was significantly increased in the latter passage, implying natural selection of the more aggressive cells.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords