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Abstract #3587

A genetic algorithm-optimized hetero-nuclear polarization transfer pulse sequence for metabolic imaging

Vencel Somai1,2, Felix Kreis3, Adam Gaunt1, and Kevin M Brindle1,4
1Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, United Kingdom, 2Department of Radiology, University of Cambridge, School of Clinical Medicine Box 218, Cambridge Biomedical Campus, Cambridge, United Kingdom, 3Department of Information Technology and Electrical Engineering, ETH Zurich, Rämistrasse 101, Zurich, Switzerland, 4Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, United Kingdom

An optimized polarization transfer pulse designed using a genetic algorithm is presented, which has greater immunity to the effects of B0 and B1 field inhomogeneity and ~2 times lower peak B1 compared to the BINEPT pulse sequence. The optimization provides a simple framework that accounts for finite pulse lengths and relaxation and outputs a shaped pulse on each frequency channel. Performance was tested on a [15N2]urea phantom at thermal equilibrium, where the polarization transferred from protons to 15N was 1.32 times greater than that transferred using BINEPT. Partial transfer of polarization from hyperpolarized 15N to proton was also demonstrated.

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