Abstract #3587

A genetic algorithm-optimized hetero-nuclear polarization transfer pulse sequence for metabolic imaging

Vencel Somai^1,2, Felix Kreis³, Adam Gaunt¹, and Kevin M Brindle^1,4

¹Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, United Kingdom, ²Department of Radiology, University of Cambridge, School of Clinical Medicine Box 218, Cambridge Biomedical Campus, Cambridge, United Kingdom, ³Department of Information Technology and Electrical Engineering, ETH Zurich, Rämistrasse 101, Zurich, Switzerland, ⁴Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, United Kingdom

An optimized polarization transfer pulse designed using a genetic algorithm is presented, which has greater immunity to the effects of B₀ and B₁ field inhomogeneity and ~2 times lower peak B₁ compared to the BINEPT pulse sequence. The optimization provides a simple framework that accounts for finite pulse lengths and relaxation and outputs a shaped pulse on each frequency channel. Performance was tested on a [¹⁵N₂]urea phantom at thermal equilibrium, where the polarization transferred from protons to ¹⁵N was 1.32 times greater than that transferred using BINEPT. Partial transfer of polarization from hyperpolarized ¹⁵N to proton was also demonstrated.

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