Utilizing a multi-resolution acquisition for hyperpolarized [1-13C]pyruvate brain MRI (7.5 mm in-plane for pyruvate and 15 mm in-plane resolution for lactate & bicarbonate) minimized partial volume effects from vascular pyruvate signals while maintaining the SNR of the downstream metabolites. In the healthy volunteers studied, higher resolution HP 13C-pyruvate multi-slice EPI images improved the quantification of kinetic rates in the brain. Selected voxels near veins and in white and gray matter showed on average >20% higher kPL using higher resolution pyruvate images, consistent with reduced partial volume contributions from vascular HP 13C-pyruvate.
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