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Abstract #3586

Kinetic Analysis of Multi-resolution Hyperpolarized 13C Human Brain MRI

Jasmine Y Graham1, Adam W Autry2, Yaewon Kim2, Robert A Bok2, Yan Li2, Peder EZ Larson1,2, Daniel B Vigneron1,2, and Jeremy W Gordon2
1Bioengineering, UC San Francisco, UC Berkeley, San Francisco, CA, United States, 2Radiology and Biomedical Imaging, UC San Francisco, San Francisco, CA, United States

Utilizing a multi-resolution acquisition for hyperpolarized [1-13C]pyruvate brain MRI (7.5 mm in-plane for pyruvate and 15 mm in-plane resolution for lactate & bicarbonate) minimized partial volume effects from vascular pyruvate signals while maintaining the SNR of the downstream metabolites. In the healthy volunteers studied, higher resolution HP 13C-pyruvate multi-slice EPI images improved the quantification of kinetic rates in the brain. Selected voxels near veins and in white and gray matter showed on average >20% higher kPL using higher resolution pyruvate images, consistent with reduced partial volume contributions from vascular HP 13C-pyruvate.

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