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Abstract #3590

Hyperpolarized [1-13C] pyruvate MR spectroscopic imaging to detect metabolic changes in liver in a MCD rat model of fatty liver disease

Joao Piraquive1, Shubhangi Agarwal1, Robert Bok1, John Kurhanewicz1, Aras Mattis2,3, Jaqueline Maher3,4, Cornelius von Morze5, and Michael A. Ohliger1,3
1Department of Radiology and Biomedical Imaging, University of California San Francisco, University of California San Francisco, San Francisco, CA, United States, 2Department of Pathology, University of California San Francisco, San Francisco, CA, United States, 3Liver center, University of California, San Francisco, CA, United States, 4Department of Medicine, University of California San Francisco, San Francisco, CA, United States, 5Biomedical Magnetic Resonance Laboratory, Washington University School of Medicine, St. Louis, MO, United States

Hyperpolarized 13C MRI was used to noninvasively detect metabolic changes in a rat model of non-alchoholic steatohepatitis. Rats were fed a methionine- and choline-deficient (MCD) diet for up to 18 weeks. In this preliminary study, we showed a significant increase in fat signal fraction and borderline-signifcant decrease in 13C lactate production in rats fed the MCD diet. Findings in this work suggest that HP 13C pyruvate can be a promising tool to monitor noninvasively the progress of fatty liver disease in patients.

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Abstract