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Abstract #3591

Constrained UNFOLD (CoUNFOLD)-a New Constrained Reconstruction for Hyperpolarized 13C Pyruvate Imaging

Zhan Xu1, Christopher M Walker1, Collin J Harlan1, Keith A Michel1, Gary V Martinez1, and James A Bankson1,2
1Imaging Physics, MD Anderson Cancer Center, Houston, TX, United States, 2UT Health Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer, Houston, TX, United States

A new pharmacokinetic-model-based constrained reconstruction method CoUNFOLD is introduced for hyperpolarized 13C pyruvate imaging. This method extended classic UNFOLD method by introducing model constraint which described the signal evolution of multiple substrates. CoUNFOLD successfully accelerated the data acquisition, and the reconstruction was implemented on single channel. An in silico experiment demonstrated the accuracy of reconstruction at a reduction factor of 2. The quantitative estimation of the conversion ratio from pyruvate to lactate was achieved with high accuracy when peak pyruvate SNR was as low as 20

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