Abstract #3591

Constrained UNFOLD (CoUNFOLD)-a New Constrained Reconstruction for Hyperpolarized 13C Pyruvate Imaging

Zhan Xu¹, Christopher M Walker¹, Collin J Harlan¹, Keith A Michel¹, Gary V Martinez¹, and James A Bankson^1,2

¹Imaging Physics, MD Anderson Cancer Center, Houston, TX, United States, ²UT Health Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer, Houston, TX, United States

A new pharmacokinetic-model-based constrained reconstruction method CoUNFOLD is introduced for hyperpolarized 13C pyruvate imaging. This method extended classic UNFOLD method by introducing model constraint which described the signal evolution of multiple substrates. CoUNFOLD successfully accelerated the data acquisition, and the reconstruction was implemented on single channel. An in silico experiment demonstrated the accuracy of reconstruction at a reduction factor of 2. The quantitative estimation of the conversion ratio from pyruvate to lactate was achieved with high accuracy when peak pyruvate SNR was as low as 20

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.