Abstract #3592

Hyperpolarized 13C-pyruvate MR imaging in rodent model of ventricular fibrillation cardiac arrest: A feasibility study

Hyeong Yeon Lee¹, Najmiddin Mamadjonov², Nguyen Trong Nguyen², Luu-Ngoc Do³, Tien Ahn Nguyen³, and Ilwoo Park^3,4,5

¹Emergency Medicine, Chonnam National University Hospital, Gwangju, Korea, Republic of, ²Biomedical Science, Chonnam National University, Gwangju, Korea, Republic of, ³Radiology, Chonnam National University, Gwangju, Korea, Republic of, ⁴Radiology, Chonnam National University Hospital, Gwangju, Korea, Republic of, ⁵Artificial Intelligence Convergence, Chonnam National University, Gwangju, Korea, Republic of

This study demonstrated that hyperpolarized 13C metabolic imaging can identify the metabolic changes within 1 hour of return of spontaneous circulation in rodent model of ventricular fibrillation-induced cardiac arrest. Brain histology performed at 72 hours after ROSC showed marked difference in the levels of neuronal death and reactive astrocyte change between the cardiac arrest model and sham control. The results from this study suggest that this new metabolic imaging technique may provide a unique and noninvasive imaging biomarker for assessing functional changes at early stage of post ROSC and warrant further investigation.

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