Abstract #3626

Evaluating the Myocardial Diffusion Status in Cardiac Amyloidosis: A Novel Intravoxel Incoherent Motion Diffusion-weighted MR Imaging Study

Mengdi Jiang¹, Xianghua Huang², Guifen Yang³, Weiqiang Dou⁴, and Yong Shen⁵

¹Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, NanJing, China, ²National Clinical Research Center of Kidney Disease, Jinling Hospital, Medical School of Nanjing University, NanJing, China, ³Department of Nuclear Medical, Jinling Hospital, Medical School of Nanjing University, NanJing, China, ⁴GE Healthcare,MR Research China, BeiJing, China, ⁵GE Healthcare,MR Enhanced Application China, BeiJing, China

The purpose of this study was to evaluate the diagnostic value of myocardial diffusion and mechanical properties by using IVIM-DWI imaging, feature tracking and native T1 in patients with cardiac amyloidosis (CA). The relationships of strain, native T1, IVIM-derived parameters (ADC_slow, ADC_fast and F) and late gadolinium enhancement (LGE) were analyzed based on six mid-ventricle subregions. Significantly different IVIM related parameters were found in patients than healthy controls. Furthermore, IVIM parameters also showed significant correlation with peak strain and nativeT1. With these findings, IVIM parameters has proven as effective biomarkers in the diagnosis of cardiac microcirculation in CA patients.

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