The purpose of this study was to evaluate the diagnostic value of myocardial diffusion and mechanical properties by using IVIM-DWI imaging, feature tracking and native T1 in patients with cardiac amyloidosis (CA). The relationships of strain, native T1, IVIM-derived parameters (ADCslow, ADCfast and F) and late gadolinium enhancement (LGE) were analyzed based on six mid-ventricle subregions. Significantly different IVIM related parameters were found in patients than healthy controls. Furthermore, IVIM parameters also showed significant correlation with peak strain and nativeT1. With these findings, IVIM parameters has proven as effective biomarkers in the diagnosis of cardiac microcirculation in CA patients.