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Abstract #3625

Increased SNR and improved reproducibility for cardiac 31P MRS at 7T using compartmentalized spectroscopy

Andrew Tyler1,2, Justin Y C Lau1, Jane Ellis1, Jack J Miller1,2,3, Paul A. Bottomley4, Christopher T Rodgers1,5, Damian J Tyler1,2, and Ladislav Valkovic1,6
1Oxford Centre for Clinical Cardiac Magnetic Resonance Research, University of Oxford, Oxford, United Kingdom, 2Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, United Kingdom, 3Department of Physics, University of Oxford, Oxford, United Kingdom, 4The Division of MR Research, Johns Hopkins Medicine, Baltimore, MD, United States, 5Wolfson Brain Imaging Centre, University of Cambidge, Cambridge, United Kingdom, 6Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia

The intrinsically low SNR and long acquisition times of 31P spectroscopy make translation to clinical practice very challenging, even at ultra-high fields. In this study, 12 healthy volunteers were scanned twice at 7T with a short 31P CSI and reduced k-space acquisitions for reconstruction with the SLAM and SLIM algorithms. PCr/ATP ratio and PCr SNR were computed for each scan and coefficients of reproducibility and variability were calculated. Compared to a Fourier based reconstruction of the short 31P acquisition, SNR was significantly improved and PCr/ATP was maintained when SLAM and SLIM reconstructions were used.

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