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Abstract #3624

Metabolic changes in coronary artery disease assessed using 1H NMR Metabolomics

Pawan Kumar1, Uma Sharma1, Rajeev Narang2, and Sujeet Mewar1
1Nuclear Magnetic Resonance and MRI Facility, All India Institute of Medical Sciences, New Delhi, India, 2Cardiology, All India Institute of Medical Sciences, New Delhi, India

Coronary artery disease (CAD) is caused by building up of plaque in the arteries of the heart, which narrows the lumen of arteries. Present study investigated the metabolic profile of blood plasma using 1H-NMR spectroscopy for distinguishing coronary artery disease (CAD) patients from healthy control (N). The results showed significant differences in the concentration of several metabolites like lactate, pyruvate, choline, acetate and alanine in the blood plasma of CAD patients in comparison to healthy controls suggesting alterations of several metabolic pathways including glycolysis, gluconeogenesis which may be related to the development of CAD.

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