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Abstract #3638

Validation of between-bundle differences and within-bundle continuity of microstructural indices in ex vivo human brain tissue

Robert Jones1, Chiara Maffei1, Qiuyun Fan1, Jean Augustinack1, Barbara Wichtmann2, Aapo Nummenmaa1, Susie Huang1, and Anastasia Yendiki1
1Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States, 2Department of Radiology, University Hospital Bonn, Bonn, Germany, Bonn, Germany

We take advantage of the high spatial resolution that is feasible ex vivo on a preclinical 9.4T system to investigate between-bundle differences and within-bundle continuity of microstructural indices. In a human brain sample that has also undergone optical imaging to obtain direct measurements of axonal orientations, we identify regions occupied by motor fibers or association fibers. We collect diffusion-weighted images with two diffusion times and eight q-shells and use them to estimate the parallel and perpendicular diffusion coefficient in each fiber bundle. We show that the diffusion coefficients vary smoothly along each bundle, and have different profiles between bundles.

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