Diffusivity measurements of the human brain have been shown to increase at short diffusion time by using oscillating gradient spin echo (OGSE). The time-dependent diffusivity averaged in large white matter parcels has been measured to assess microstructure characteristics. In this study, we assessed time-dependent diffusivity in finer white matter parcels to study the regional microstructure differences. In four healthy volunteers, we consistently observed higher parallel diffusivity values and higher increasing rate over OGSE frequencies in two sub-parcels of the genu and two of the splenium in the corpus callosum, compared to other regions, indicating regional microstructure differences of the brain.
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