Meeting Banner
Abstract #3639

Oscillating Gradient Spin Echo-Based Time-dependent Diffusivity Reflects Regional Microstructure Differences in Human White Matter

Ante Zhu1, J. Kevin DeMarco2,3, Robert Y. Shih2,3, Radhika Madhavan1, Tim Sprenger4, Chitresh Bhushan1, Maureen Hood2,3, Luca Marinelli1, Vincent B. Ho2,3, and Thomas K.F. Foo1
1GE Global Research, Niskayuna, NY, United States, 2Uniformed Services University of the Health Sciences, Bethesda, MD, United States, 3Walter Reed National Military Medical Center, Bethesda, MD, United States, 4GE Healthcare, Stockholm, Sweden

Diffusivity measurements of the human brain have been shown to increase at short diffusion time by using oscillating gradient spin echo (OGSE). The time-dependent diffusivity averaged in large white matter parcels has been measured to assess microstructure characteristics. In this study, we assessed time-dependent diffusivity in finer white matter parcels to study the regional microstructure differences. In four healthy volunteers, we consistently observed higher parallel diffusivity values and higher increasing rate over OGSE frequencies in two sub-parcels of the genu and two of the splenium in the corpus callosum, compared to other regions, indicating regional microstructure differences of the brain.

This abstract and the presentation materials are available to members only; a login is required.

Join Here