Abstract #3640

A tale of two frequencies: optimizing oscillating gradients for frequency dependent differential kurtosis mapping

Kevin B Borsos^1,2, Desmond HY Tse², Paul I Dubovan^1,2, and Corey A Baron^1,2,3

¹Department of Medical Biophysics, Western University, London, ON, Canada, ²Centre for Functional and Metabolic Mapping, Western University, London, ON, Canada, ³Robarts Research Institute, Western University, London, ON, Canada

Frequency dependent diffusion kurtosis has historically been difficult to measure with oscillating gradient spin echo (OGSE) sequences and even more so without the use of gradient insert coils. Here we present a new OGSE gradient waveform and determine the optimal frequency to observe kurtosis differences between PGSE and OGSE acquisitions using a conventional gradient system. Using this method we present in vivo differential kurtosis maps based on the frequency dependence.

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