Complementary aspects of the tissue microstructure can be addressed using different models to quantify diffusion MRI. However, there is no consensus on a common acquisition scheme within a clinical feasible time to support the quantification of multiple models. We acquired a large dataset with multiple b-values and directions, and recursively subsampled it to identify the minimum acquisition scheme (MAS) for each model. Finally, we investigated the impact of the MAS on the parameter estimates in the main fiber bundles of the brain. This work supports the transition of advanced analyses to the clinical practice.