The optimal data acquisition strategy for accurate metabolic and cytometric parameter extraction using a digital DWI library is investigated using simulations under the constant data-acquisition time (same number of b-values) constraint. Base on DWI data from pancreatic tail tissue and using a seven b-value approach, the optimal maximum b-value is found to be data signal-to-noise ratio dependent, and generally should be below 3,000 s/mm2. In addition, evenly-spaced b-values are generally within the optimal b-spacing range.
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