Abstract #3645

Optimizing DWI b-value Sampling for Accurate Metabolic and Cytometric Parameter Extraction: Activity MRI [aMRI]

Xin Li¹, Eric M. Baker¹, Brendan Moloney¹, Cory Wyatt¹, Eric Baetscher¹, Erin W. Gilbert², Charles S. Springer¹, Alexander R. Guimaraes^1,3, and William D. Rooney¹

¹Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States, ²Surgery, Oregon Health & Science University, Portland, OR, United States, ³Diagnostic Radiology, Oregon Health & Science University, Portland, OR, United States

The optimal data acquisition strategy for accurate metabolic and cytometric parameter extraction using a digital DWI library is investigated using simulations under the constant data-acquisition time (same number of b-values) constraint. Base on DWI data from pancreatic tail tissue and using a seven b-value approach, the optimal maximum b-value is found to be data signal-to-noise ratio dependent, and generally should be below 3,000 s/mm². In addition, evenly-spaced b-values are generally within the optimal b-spacing range.

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