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Abstract #3648

Brain microstructure at 1.5mm resolution via RMT reconstruction on a high-slew rate MAGNUS system

Gregory Lemberskiy1, Santiago Coelho1, Thomas K.F. Foo2, Radhika Madhavan2, Luca Marinelli2, Jaemin Shin3, Els Fieremans1, and Dmitry S Novikov1
1Radiology, NYU School of Medicine, New York, NY, United States, 2GE Research, Niskayuna, NY, United States, 3GE Healthcare, New York, NY, United States

A multishell diffusion neuro protocol at 1.5 mm isotropic resolution was acquired in 10 minutes with a high performance MAGNUS head gradient coil (200 mT/m with 500 mT/m/ms slew) at 3.0 T, and reconstructed using random matrix theory (RMT) denoising at the coil level. The SNR enhancement due to RMT reconstruction, and the nearly distortion-free images due to high slew rate, yield precise diffusion and kurtosis maps, fiber-dispersion, as well as microstructure parameters estimated using 3-compartment Standard Model of diffusion. We draw compartment fractions and diffusivities on fiber-tracts reconstructed based on fiber ODFs estimated by deconvolving model-based local fiber response.

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