Abstract #3649

Comparison of DCE-MRI and FEXI in the measurement of vascular water exchange in high-grade glioma

Zejun Wang¹, Bao Wang², Yingchao Liu³, and Ruiliang Bai^1,4

¹Key Laboratory of Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China, ²Department of Radiology, Qilu Hospital of Shandong University, Jinan, China, ³Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China, ⁴Department of Physical Medicine and Rehabilitation, Interdisciplinary Institute of Neuroscience and Technology, The Affiliated Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China

Vascular water exchange is a highly sensitive marker of BBB dysfunction and a potential biomarker of metabolic activity. In this study, we compared two different MRI methods for vascular water exchange measurement, including shutter speed (SS) DCE-MRI and filter-exchange imaging (FEXI) in high-grade glioma patents. Our results demonstrated consistent vascular water exchange assessments by SS DCE-MRI and FEXI in both normal-appearing white matter and tumor.

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