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Abstract #3649

Comparison of DCE-MRI and FEXI in the measurement of vascular water exchange in high-grade glioma

Zejun Wang1, Bao Wang2, Yingchao Liu3, and Ruiliang Bai1,4
1Key Laboratory of Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China, 2Department of Radiology, Qilu Hospital of Shandong University, Jinan, China, 3Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China, 4Department of Physical Medicine and Rehabilitation, Interdisciplinary Institute of Neuroscience and Technology, The Affiliated Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China

Vascular water exchange is a highly sensitive marker of BBB dysfunction and a potential biomarker of metabolic activity. In this study, we compared two different MRI methods for vascular water exchange measurement, including shutter speed (SS) DCE-MRI and filter-exchange imaging (FEXI) in high-grade glioma patents. Our results demonstrated consistent vascular water exchange assessments by SS DCE-MRI and FEXI in both normal-appearing white matter and tumor.

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