Abstract #3653

Toward high-resolution mapping of microscopic anisotropy in the cortex using b-tensor diffusion imaging with a spiral readout at 7 Tesla

Sajjad Feizollah^1,2 and Christine L. Tardif^1,2,3

¹Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada, ²McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, QC, Canada, ³Department of Biomedical Engineering, McGill University, Montreal, QC, Canada

High-resolution diffusion-weighted imaging has been used to investigate the microstructure of the cortex in vivo. However, conventional linear diffusion encoding provides limited insight into the underlying microstructural differences between cortical areas. b-Tensor encoding disentangles macroscopic from microscopic anisotropy in voxels with complex fiber geometries. The SNR and thus resolution of these scans are limited by the longer diffusion encoding times. A DWI sequence with b-tensor encoding was implemented at 7T with a spiral readout trajectory and dynamic field monitoring to image cortical microstructure. Microscopic anisotropy maps of the brain are presented at 1.4 mm isotropic, within minimal distortions and blurring.

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