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Abstract #3653

Toward high-resolution mapping of microscopic anisotropy in the cortex using b-tensor diffusion imaging with a spiral readout at 7 Tesla

Sajjad Feizollah1,2 and Christine L. Tardif1,2,3
1Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada, 2McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, QC, Canada, 3Department of Biomedical Engineering, McGill University, Montreal, QC, Canada

High-resolution diffusion-weighted imaging has been used to investigate the microstructure of the cortex in vivo. However, conventional linear diffusion encoding provides limited insight into the underlying microstructural differences between cortical areas. b-Tensor encoding disentangles macroscopic from microscopic anisotropy in voxels with complex fiber geometries. The SNR and thus resolution of these scans are limited by the longer diffusion encoding times. A DWI sequence with b-tensor encoding was implemented at 7T with a spiral readout trajectory and dynamic field monitoring to image cortical microstructure. Microscopic anisotropy maps of the brain are presented at 1.4 mm isotropic, within minimal distortions and blurring.

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