Five out of eight axial-symmetric Diffusion Kurtosis Imaging (AxDKI) parameters are directly related to biophysical microstructure parameters including intra- and extra-axonal diffusivities, fiber dispersion and axonal-water fraction. Their estimation, however, is biased at small signal-to-noise ratios (SNR). Here, based on simulations, we investigated the Rician noise bias’s effect and its correction (RBC) on estimated AxDKI and biophysical parameters at varying SNRs for the standard and AxDKI model. Our study suggests AxDKI to be better than standard DKI, here least biased AxDKI estimators were produced with RBC while for biophysical parameters results were branch-dependent (SNR≥23 with RBC and SNR≥33 without RBC).
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