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Abstract #3656

Development of in vivo human brain DTI-MRE: Optimization of experimental parameters

Shujun Lin1, Bradley Sutton2, Richard Magin1, Aaron Anderson2, and Dieter Klatt1
1Richard and Loan Hill Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, United States, 2Beckman Institute, University of Illinois at Urbana-Champaign, Urbana-Champaign, IL, United States

Simultaneous acquisition of diffusion tensor imaging (DTI) and magnetic resonance elastography (MRE) has been proven feasible in a preliminary study of in vivo human brain. However, the experimental parameters have to be optimized in order to prevent mutual interferences of DTI and MRE acquisitions. We identified in simulations three experimental parameter sets for in vivo human brain DTI-MRE that we classify as good, moderate and poor with regard to optimization and present a pilot study using these parameter sets. The experimental results verify the simulations as we found the best performance of DTI-MRE for the good parameters set.

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