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Abstract #3657

Correcting B0 inhomogeneity-induced distortions in whole-body diffusion MRI of bone metastases

Leonardino A. Digma1, Christine H. Feng1, Christopher C. Conlin2, Ana E. Rodriguez-Soto2, Kanha Batra3, Aaron Simon1, Roshan Karunamuni1, Joshua Kuperman2, Rebecca Rakow-Penner2, Michael E. Hahn2, Anders M. Dale2, and Tyler M. Seibert1,4
1Department of Radiation Medicine and Applied Sciences, UCSD School of Medicine, La Jolla, CA, United States, 2Department of Radiology, UCSD School of Medicine, La Jolla, CA, United States, 3Department of Electrical and Computer Engineering, UC San Diego, La Jolla, CA, United States, 4Department of Bioengineering, UC San Diego, La Jolla, CA, United States

Bone is among the most common sites of cancer metastases. Diffusion weighted imaging (DWI) can be used to detect these metastases. However, when acquired with echo-planar imaging, DWI suffers distortions due to static magnetic field inhomogeneities. In this study, we first used the reverse polarity gradient (RPG) technique to measure spatial distortions of bone metastases on DWI. Next, we demonstrated that RPG can be used to correct these distortions and produce diffusion images that more accurately reflect the underlying anatomy. Taken together, findings support the use of distortion correction techniques to improve localization of bone metastases on DWI.

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