Meeting Banner
Abstract #3658

Developing a multi-parametric model of response based on biomarkers derived from Whole-Body Diffusion Weighted Imaging

Antonio Candito1, Matthew D Blackledge1, Fabio Zugni2, Richard Holbrey1, Sebastian Schäfer3, Matthew R Orton1, Ana Ribeiro4, Matthias Baumhauer3, Nina Tunariu1, and Dow-Mu Koh1
1The Institute of Cancer Research, London, United Kingdom, 2IEO, European Institute of Oncology IRCCS, Milan, Italy, 3Mint Medical, Heidelberg, Germany, 4The Royal Marsden NHS Foundation Trust, London, United Kingdom

We develop a model of treatment response in patients with advanced prostate cancer (APC), based on measurements of median Apparent Diffusion Coefficient (ADC) and tumour Diffusion Volume (tDV) derived using Whole-Body Diffusion Weighted Imaging (WBDWI) and blood biomarkers. The model showed that change in ADC is positively correlated with response in this patient population. Furthermore, our model predicted response with an accuracy of 87%, and sensitivity/specificity of 75/93% using a probability cut-off of 0.5.

This abstract and the presentation materials are available to members only; a login is required.

Join Here