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Abstract #3662

Methodological considerations on segmenting MRI data of rhabdomyosarcoma

Cyrano Chatziantoniou1,2, Reineke Schoot2, Roelof van Ewijk2, Simone ter Horst2, Rick van Rijn3, Hans Merks2, Alexander Leemans1, and Alberto de Luca1
1Image Science Institute, UMC Utrecht, Utrecht, Netherlands, 2Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands, 3Department of Radiology, Academic Medical Centre Amsterdam, Amsterdam, Netherlands

Rhabdomyosarcoma is a rare form of cancer that is particularly prevalent in children. There is a pressing need for new imaging biomarkers for monitoring treatment response, such diffusion. No standards currently exist to annotate rhabdomyosarcoma on MRI and measure the diffusion.

This work analyses segmentation strategies in recent literature on saromas and compares them on a toy example. It shows that there is a large inconsistency in the application of segmentation strategies and that the different methods for segmenting the tumor can yield high variation in measured diffusion.

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