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Abstract #3663

Non-gaussian IVIM DW-and fast exchange regime DCE- MRI for predicting of locoregional failure in nasopharyngeal carcinoma

Ramesh Paudyal1, Linda Chen2, Jung Hun Oh1, Kaveh Zakeri2, Vaios Hatzoglou3, Chiaojung Jillian Tsai2, Nancy Lee2, and Amita Shukla-Dave1,3
1Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, United States, 2Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, United States, 3Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States

The study aims to assess quantitative imaging (QI) metrics from pre-treatment (TX) non-gaussian intravoxel incoherent DW- and fast exchange regime (FXR) DCE-MRI for predicting locoregional failure (LRF) in nasopharyngeal carcinoma (NPC) patients. Cumulative incidence analysis (CIA) was performed on the two subgroups dichotomized with Youden’s index. Competing-risks regression based on Fine and Gray’s (FG) proportional sub hazards model was used to estimate survival subdistribution hazard ratios (SHRs). The pre-TX ADC, D, f, and ti cutoff values from CIA analysis and K cutoff value from the competing risk regression analysis indicated these QI’s could predict the LRF in NPC patients.

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