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Abstract #3665

Qualitative and quantitative comparison between IVIM-DKI and PET/CT imaging in lymphoma

Archana Vadiraj Malagi1, Devasenathipathy Kandasamy2, Kedar Khare3, Deepam Pushpam4, Rakesh Kumar5, Sameer Bakhshi4, and Amit Mehndiratta1,6
1Centre for Biomedical Engineering, Indian Institute of Technology Delhi, New Delhi, India, 2Department of Radiodiagnosis, All India Institute of Medical Sciences Delhi, New Delhi, India, 3Department of Physics, Indian Institute of Technology Delhi, New Delhi, India, 4Department of Medical Oncology, Dr. B.R. Ambedkar Institute-Rotary Cancer Hospital (IRCH), All India Institute of Medical Sciences Delhi, New Delhi, India, 5Department of Nuclear Medicine, All India Institute of Medical Sciences Delhi, New Delhi, India, 6Department of Biomedical Engineering, All India Institute of Medical Sciences Delhi, New Delhi, India

PET/CT plays an important role in diagnosis and assessment of treatment response in lymphoma. The goal of this study was to evaluate the role of IVIM-DKI parameters in comparison to PET parameters in lymphoma. PET images were registered onto IVIM-DKI at b=0s/mm2 images for tumor ROI using 3D-multimodal affine registration. Qualitatively, IVIM parameters with state-of-the-art Total-Variation produced better quality parameter maps. Tumor appeared hyperintense in SUV and K maps and hypointense in diffusion and perfusion parameters. No correlation was observed between IVIM-DKI with PET parameters. IVIM with Total-Variation showed substantial reproducibility as compared to conventional IVIM, DKI and SUV parameters.

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