Abstract #3665

Qualitative and quantitative comparison between IVIM-DKI and PET/CT imaging in lymphoma

Archana Vadiraj Malagi¹, Devasenathipathy Kandasamy², Kedar Khare³, Deepam Pushpam⁴, Rakesh Kumar⁵, Sameer Bakhshi⁴, and Amit Mehndiratta^1,6

¹Centre for Biomedical Engineering, Indian Institute of Technology Delhi, New Delhi, India, ²Department of Radiodiagnosis, All India Institute of Medical Sciences Delhi, New Delhi, India, ³Department of Physics, Indian Institute of Technology Delhi, New Delhi, India, ⁴Department of Medical Oncology, Dr. B.R. Ambedkar Institute-Rotary Cancer Hospital (IRCH), All India Institute of Medical Sciences Delhi, New Delhi, India, ⁵Department of Nuclear Medicine, All India Institute of Medical Sciences Delhi, New Delhi, India, ⁶Department of Biomedical Engineering, All India Institute of Medical Sciences Delhi, New Delhi, India

PET/CT plays an important role in diagnosis and assessment of treatment response in lymphoma. The goal of this study was to evaluate the role of IVIM-DKI parameters in comparison to PET parameters in lymphoma. PET images were registered onto IVIM-DKI at b=0s/mm² images for tumor ROI using 3D-multimodal affine registration. Qualitatively, IVIM parameters with state-of-the-art Total-Variation produced better quality parameter maps. Tumor appeared hyperintense in SUV and K maps and hypointense in diffusion and perfusion parameters. No correlation was observed between IVIM-DKI with PET parameters. IVIM with Total-Variation showed substantial reproducibility as compared to conventional IVIM, DKI and SUV parameters.

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