Abstract #3666

Preliminary Study on Monitoring Drug Resistance of Colon Cancer with Intravoxel Incoherent Motion MRI In Vivo

Qi Xie¹, Wenjuan He¹, Zhilin Tan¹, Yajie Wang¹, Jinbin Wu¹, Xiyan Shao², Yiming Yang³, Jing Zhang⁴, Kangwei Wang⁵, Guiqin Wang⁶, Qifeng Pan¹, and Yunzhu Wu⁷

¹Medical Imaging Department, Nansha Hospital, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China, ²Ultrasound Imaging Department, Longgang District People’s Hospital, Shenzhen, China, ³Department of Radiology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, China, ⁴Department of Pathology, Cancer Center, Sun Yat-sen University, Guangzhou, China, ⁵Department of Pathology, Nansha Hospital, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China, ⁶Medical Record Department, Nansha Hospital, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China, ⁷MR Scientific Marketing, SIEMENS Healthcare Ltd., Guangzhou, China

This study has demonstrated that ADC value of DWI with single-exponential model and diffusion coefficient D of IVIM are valuable for discriminating 5-FU-responsive and 5-FU-resistant colon cancer in vivo. IVIM is expected to be a simple and practical way to quantitatively monitor tumor resistance in vivo, and ADC &D value may be an imaging biomarker.

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