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Abstract #3666

Preliminary Study on Monitoring Drug Resistance of Colon Cancer with Intravoxel Incoherent Motion MRI In Vivo

Qi Xie1, Wenjuan He1, Zhilin Tan1, Yajie Wang1, Jinbin Wu1, Xiyan Shao2, Yiming Yang3, Jing Zhang4, Kangwei Wang5, Guiqin Wang6, Qifeng Pan1, and Yunzhu Wu7
1Medical Imaging Department, Nansha Hospital, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China, 2Ultrasound Imaging Department, Longgang District People’s Hospital, Shenzhen, China, 3Department of Radiology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, China, 4Department of Pathology, Cancer Center, Sun Yat-sen University, Guangzhou, China, 5Department of Pathology, Nansha Hospital, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China, 6Medical Record Department, Nansha Hospital, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China, 7MR Scientific Marketing, SIEMENS Healthcare Ltd., Guangzhou, China

This study has demonstrated that ADC value of DWI with single-exponential model and diffusion coefficient D of IVIM are valuable for discriminating 5-FU-responsive and 5-FU-resistant colon cancer in vivo. IVIM is expected to be a simple and practical way to quantitatively monitor tumor resistance in vivo, and ADC &D value may be an imaging biomarker.

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