Abstract #3668

Diffusion and perfusion MRI predicts response preceding and shortly after stereotactic radiosurgery to brain metastases

Amaresha Shridhar Konar¹, Akash Deelip Shah², Ramesh Paudyal¹, Jung Hun Oh¹, Eve LoCastro¹, David Aramburu Nuñez¹, Nathaniel Swinburne², Robert J. Young², Andrei I. Holodny², Kathryn Beal³, Vaios Hatzoglou², and Amita Shukla-Dave^1,2

¹Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, United States, ²Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States, ³Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, United States

In the clinical settings it is essential to accurately assess, whether or not a brain metastases has been successfully treated or whether it requires additional treatment, especially in high dose radiation therapy, such as stereotactic radiosurgery (SRS). The present prospective study aims to determine the ability of Diffusion Weighted (DW)- and Dynamic Contrast Enhanced (DCE)-MRI to predict the long-term response of brain metastases within 72 hours of SRS. The preliminary results are promising as it will inform the treating physicians at an early time point about which patients will benefit from SRS (or not).

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