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Abstract #3668

Diffusion and perfusion MRI predicts response preceding and shortly after stereotactic radiosurgery to brain metastases

Amaresha Shridhar Konar1, Akash Deelip Shah2, Ramesh Paudyal1, Jung Hun Oh1, Eve LoCastro1, David Aramburu Nuñez1, Nathaniel Swinburne2, Robert J. Young2, Andrei I. Holodny2, Kathryn Beal3, Vaios Hatzoglou2, and Amita Shukla-Dave1,2
1Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, United States, 2Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States, 3Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, United States

In the clinical settings it is essential to accurately assess, whether or not a brain metastases has been successfully treated or whether it requires additional treatment, especially in high dose radiation therapy, such as stereotactic radiosurgery (SRS). The present prospective study aims to determine the ability of Diffusion Weighted (DW)- and Dynamic Contrast Enhanced (DCE)-MRI to predict the long-term response of brain metastases within 72 hours of SRS. The preliminary results are promising as it will inform the treating physicians at an early time point about which patients will benefit from SRS (or not).

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