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Abstract #3669

The utility of IVIM maps in the assessment of microvascular perfusion of brain glioma

Andre Monteiro Paschoal1,2, Raquel Andrade Moreno3,4, Antonio Carlos dos Santos5, and Renata Ferranti Leoni6
1LIM44, Instituto e Departamento de Radiologia, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil, 2InBrain Lab, University of Sao Paulo, Ribeirao Preto, Brazil, 3Instituto do Cancer do Estado de Sao Paulo, Sao Paulo, Brazil, 4Memorial Sloan-Kettering Cancer Center, New York, NY, United States, 5Departamento de Clinica Medica, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, Brazil, 6InBrain Lab - University of Sao Paulo, Ribeirao Preto, Brazil

The assessment perfusion in glioma is an important information in the tumor characterization. Traditional MRI methods employed to analyze glioma are based on the application of contrast agents to enhance the T1 signal and/or to measure perfusion within the tumor cells. The analysis of tumor microvasculature however is hampered by the size of contrast agent molecules. In that sense, SWI can be employed, although it does not provide quantitative information. IVIM maps showed to be an interesting alternative for such assessment, even showing potential of an early biomarker to assess early changes in perfusion, specially in low grade gliomas.

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