We evaluated the contribution of blood to the NOE(-1.6) from rat brains by using two blood suppression approaches: (1) signal acquisition with a diffusion-weighting of b=400s/mm2; (2) intravascular injection of 5mg/kg MION, and by measurements on an ex vivo blood sample. Results show that the NOE(-1.6) does not change significantly with diffusion weighting and is relatively weaker in ex vivo blood than that in brain, but decreases significantly in vivo after injection of MION. This study suggests that NOE(-1.6) is not mainly from blood, and that MION particles alter the NOE(-1.6) but have much weaker effects on other CEST effects.
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