The results of this study suggest the non-invasive assessment of tissue pH may provide value for monitoring the progression of diseases such as brain cancer that involve pH modification. This study also demonstrates that tissue acidification in a rat C6 glioma model and in contralateral tissue can be measured following drug injection by endogenous pH-weighted contrast produced by CEST-MRI. It is noteworthy that drugs like cariporide can acidify tumours and normal tissue. However, such drugs could enhance the efficacy of existing standard treatments in different human malignancies.
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