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Abstract #3695

The Effect of Cariporide on Tumour Intracellular pH: A Study in Rat C6 Glioma using AACID-CEST-MRI

Maryam Mozaffari1,2, Nivin Nystrom1,2, Alex Li1, Miranda Bellyou1, Timothy Scholl1,2, and Robert Bartha1,2
1Robarts Research Institute, London, ON, Canada, 2Department of Medical Biophysics, Western University, London, ON, Canada

The results of this study suggest the non-invasive assessment of tissue pH may provide value for monitoring the progression of diseases such as brain cancer that involve pH modification. This study also demonstrates that tissue acidification in a rat C6 glioma model and in contralateral tissue can be measured following drug injection by endogenous pH-weighted contrast produced by CEST-MRI. It is noteworthy that drugs like cariporide can acidify tumours and normal tissue. However, such drugs could enhance the efficacy of existing standard treatments in different human malignancies.

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