Abstract #3696

Numerical Fit of Extrapolated Semisolid Magnetization Transfer Reference Signal (NEMR) for Improved pH-Weighted Imaging of Ischemic Stroke

Xingwang Yong¹, Shanshan Lu², Yi-Cheng Hsu³, Yi Sun³, Dan Wu¹, and Yi Zhang¹

¹Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, Zhejiang, China, ²The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China, ³MR Collaboration, Siemens Healthcare Ltd., Shanghai, China

Amide proton transfer (APT) imaging can detect pH-related changes in ischemic stroke lesions. However, the widely-used magnetization transfer ratio asymmetry (MTR_asym) analysis method is susceptible to various contamination sources. Here we improved the previous extrapolated semisolid magnetization transfer reference (EMR) method by numerical fitting of the EMR signal (NEMR) in the modified Bloch-McConnel equation. The proposed NEMR method was compared with the previous EMR method in Monte Carlo simulations, demonstrating superior accuracy. Furthermore, the NEMR maps were compared with EMR and MTR_asym maps in nine ischemic stroke patients, yielding a better depiction of the ischemic lesions.

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