Meeting Banner
Abstract #3698

Using Glutamate-Weighted MR Imaging (GluCEST) to Detect Effects of Transcranial Magnetic Stimulation 

Abigail T.J. Cember1, Benjamin Deck2, Jared Zimmerman3, Brian Erickson2, Apoorva Kelkar2, Olufunsho Faseyitan3, Mark Elliott1, Ravinder Reddy1, and John D. Medaglia2
1Center for Magnetic Resonance and Optical Imaging, Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Department of Psychology, Drexel University, Philadelphia, PA, United States, 3Laboratory for Cognition and Neural Stimulation, Department of Neurology, University of Pennsylvania, Philadelphia, PA, United States

GluCEST was used to measure the effects of transcranial magnetic stimulation (TMS) to the motor cortex in healthy volunteers. Volunteers were scanned before and after stimulation or a sham, non-stimulating procedure. The data were analyzed by registering gluCEST maps to a cortical gray matter segmentation from Freesurfer and performing regional analysis. We find that this form of TMS, known as continuous theta-burst stimulation, had a consistent but non-local effect of decreasing the gluCEST signal in the brains of volunteers who received the stimulation in comparison to those who received a sham (placebo) procedure.

This abstract and the presentation materials are available to members only; a login is required.

Join Here