Abstract #3698

Using Glutamate-Weighted MR Imaging (GluCEST) to Detect Effects of Transcranial Magnetic Stimulation

Abigail T.J. Cember¹, Benjamin Deck², Jared Zimmerman³, Brian Erickson², Apoorva Kelkar², Olufunsho Faseyitan³, Mark Elliott¹, Ravinder Reddy¹, and John D. Medaglia²

¹Center for Magnetic Resonance and Optical Imaging, Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, ²Department of Psychology, Drexel University, Philadelphia, PA, United States, ³Laboratory for Cognition and Neural Stimulation, Department of Neurology, University of Pennsylvania, Philadelphia, PA, United States

GluCEST was used to measure the effects of transcranial magnetic stimulation (TMS) to the motor cortex in healthy volunteers. Volunteers were scanned before and after stimulation or a sham, non-stimulating procedure. The data were analyzed by registering gluCEST maps to a cortical gray matter segmentation from Freesurfer and performing regional analysis. We find that this form of TMS, known as continuous theta-burst stimulation, had a consistent but non-local effect of decreasing the gluCEST signal in the brains of volunteers who received the stimulation in comparison to those who received a sham (placebo) procedure.

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