Abstract #3699

A digital human head phantom for validation of retrospective motion correction in glucoCEST MRI

Patrick M. Lehmann¹, Mads Andersen², Anina Seidemo¹, Xiang Xu^3,4, Xu Li^4,5, Nirbhay Yadav^4,5, Ronnie Wirestam¹, Frederik Testud⁶, Patrick A. Liebig⁷, Pia C. Sundgren^8,9, Peter C. M. van Zijl^4,5, and Linda Knutsson^1,4

¹Department of Medical Radiation Physics, Lund University, Lund, Sweden, ²Philips Healthcare, Copenhagen, Denmark, ³BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ⁴Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁵F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ⁶Siemens Healthcare AB, Malmö, Sweden, ⁷Siemens Healthcare GmbH, Erlangen, Germany, ⁸Department of Radiology, Lund University, Lund, Sweden, ⁹Lund University Bioimaging Centre, Lund University, Lund, Sweden

D-glucose was recently suggested as a CEST-based biodegradable alternative to gadolinium-based contrast agents. Dynamic glucose-enhanced (DGE) MRI can retrieve information about glucose uptake, determined by tissue perfusion, transport, and metabolism. Motion artefacts in DGE-MRI can be mistaken for CEST effects, while motion correction may erroneously alter true DGE signal. A digital human head phantom based on a realistic glucose infusion protocol was developed to analyse motion artefacts and validate rigid-head retrospective motion correction. This phantom can be used for testing different correction approaches using various motion patterns and contrast responses to better understand these effects in vivo.

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