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Abstract #3699

A digital human head phantom for validation of retrospective motion correction in glucoCEST MRI 

Patrick M. Lehmann1, Mads Andersen2, Anina Seidemo1, Xiang Xu3,4, Xu Li4,5, Nirbhay Yadav4,5, Ronnie Wirestam1, Frederik Testud6, Patrick A. Liebig7, Pia C. Sundgren8,9, Peter C. M. van Zijl4,5, and Linda Knutsson1,4
1Department of Medical Radiation Physics, Lund University, Lund, Sweden, 2Philips Healthcare, Copenhagen, Denmark, 3BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 4Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 5F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 6Siemens Healthcare AB, Malmö, Sweden, 7Siemens Healthcare GmbH, Erlangen, Germany, 8Department of Radiology, Lund University, Lund, Sweden, 9Lund University Bioimaging Centre, Lund University, Lund, Sweden

D-glucose was recently suggested as a CEST-based biodegradable alternative to gadolinium-based contrast agents. Dynamic glucose-enhanced (DGE) MRI can retrieve information about glucose uptake, determined by tissue perfusion, transport, and metabolism. Motion artefacts in DGE-MRI can be mistaken for CEST effects, while motion correction may erroneously alter true DGE signal. A digital human head phantom based on a realistic glucose infusion protocol was developed to analyse motion artefacts and validate rigid-head retrospective motion correction. This phantom can be used for testing different correction approaches using various motion patterns and contrast responses to better understand these effects in vivo.

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