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Abstract #3700

Volumetric glutamate-weighted MR imaging (gluCEST) enables in vivo detection of metabolic differences between human hippocampal subfields

Abigail T.J. Cember1, Ravi Prakash Reddy Nanga1, Hari Hariharan1, Neil E. Wilson2, Puneet Bagga3, and Ravinder Reddy1
1Center for Magnetic Resonance and Optical Imaging, Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Siemens Medical Solutions, USA, Malvern, PA, United States, 3Department of Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, TN, United States

We performed volumetric (3D) gluCEST with novel post-processing to image a slab containing the medial temporal lobe (MTL) in healthy human subjects. This data was segmented using a 7T atlas for hippocampal subfields. Upon further regional analysis, it was found that statistically significant differences exist between the mean gluCEST of MTL subfields; most prominently, that the dentate gyrus has greater gluCEST contrast than neighboring regions. We believe after some preliminary validation that this trend is independent of the B1 distribution or other variables. Moreover, it corroborates existing models of brain physiology identifying the DG as the locus of neurogenesis.

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