We performed volumetric (3D) gluCEST with novel post-processing to image a slab containing the medial temporal lobe (MTL) in healthy human subjects. This data was segmented using a 7T atlas for hippocampal subfields. Upon further regional analysis, it was found that statistically significant differences exist between the mean gluCEST of MTL subfields; most prominently, that the dentate gyrus has greater gluCEST contrast than neighboring regions. We believe after some preliminary validation that this trend is independent of the B1 distribution or other variables. Moreover, it corroborates existing models of brain physiology identifying the DG as the locus of neurogenesis.
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