Abstract #3701

Automated CEST Measurements for the Lateralization of Epileptic Foci in Temporal Lobe Epilepsy at 3 T

Qingqing Wen¹, Kang Wang², Wenqi Wang¹, Yi Sun³, Dan Wu^1,2, and Yi Zhang^1,2

¹Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, ²Department of Neurology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China, ³MR Collaboration, Siemens Healthcare Ltd., Shanghai, China

Chemical Exchange Saturation Transfer (CEST) imaging at 3T was applied to patients with temporal lobe epilepsy (TLE). Hippocampus and amygdala were automatically segmented, and then the magnetization transfer ratio asymmetry (MTR_asym), T₁, and T₂ values in these regions of interest were determined. It was found that MTR_asym in the hippocampus and amygdala was much more accurate than the quantitative T₁ and T₂ maps in predicting the seizure laterality, with an AUC value of 0.80 and a success rate of 17/20. The study indicated that CEST at 3T could potentially aid the clinical assessment of the epileptic foci in TLE patients.

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